相关实验视频
Updated: Aug 18, 2026
09:46
Accessing the Cytotoxicity and Cell Response to Biomaterials
Published on: July 8, 2021
3.8K
基于酸的水泥与不同的放射性平静剂的系统效应 - - 鼠类的基因病理分析
Osman Ataş1, Kubra Bılge2, Semsettin Yıldız1
1Faculty of Dentistry, Department of Pediatric Dentistry, Firat (Euphrates) University, Elazig, Turkey.
PeerJ
|June 14, 2023
概括
使用各种放射性平静剂的酸盐水泥 (CSC) 对大鼠脏和肝脏组织表现出可接受的全身效应. 组织病理学和血清分析表明,这些牙科材料没有显著的不良影响.
科学领域:
- 生物材料科学 生物材料科学
- 毒理学 毒理学 毒理学
- 牙科材料 牙科材料
背景情况:
- 酸水泥 (CSCs) 在牙科中广泛使用.
- 不同的放射性平静剂可以影响CSC的特性和生物相互作用.
- 了解当代CSC的系统影响对于患者安全至关重要.
研究的目的:
- 为了研究四种当代酸盐水泥 (CSCs) 与不同放射性平静剂的系统效应.
- 评估BIOfactor MTA (BIO),Neo MTA Plus (NEO),MTA Repair HP (REP) 和Biodentine (DENT) 对大鼠肝脏和脏组织和功能的影响.
主要方法:
- 一个体内研究,涉及80只雄性Sprague Dawley大鼠皮下植入CSC填充的聚乙烯管.
- 在植入后7天和30天对肝脏和脏组织进行了组织病理学分析.
- 血清标记物 (ALT,AST,尿素,肌素) 的生物化学分析,以评估肝脏和功能.
主要成果:
- 在第7天,与对照组和DENT组相比,REP,BIO和NEO组的组织显示炎症增加;REP和NEO组在第30天显示炎症比对照组,BIO和DENT组更高.
- 肝脏炎症轻度至中度,没有显著的群体间差异.
- 与第7天的对照组相比,DENT和NEO组的肌素水平明显较低. 与其他组相比,REP组在第30天显示出明显更高的尿素和肌素水平.
结论:
- 具有不同放射性平静剂的当代CSC对大鼠脏和肝脏组织具有普遍相似和可接受的全身影响.
- 根据基因病理学和血清生物化学参数,在评估的CSC中没有观察到显著的不良系统毒性.
相关概念视频
02:41Lethal Alleles
Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
02:43Mouse Models of Cancer Study
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
02:43Mouse Models of Cancer Study
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...