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高剂量的辐射刺激了乳腺瘤的微环境,以增强瘤细胞的生长并降低瘤细胞的运动性

Sepehr Torabinejad¹, Shokouhozaman Soleymanifard², Sima Sayyah³

¹Department of Genetics, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.

Journal of biomedical physics & engineering

|June 14, 2023

概括

在乳腺癌患者中,术内放射疗法 (IORT) 与手术相结合,增强了瘤细胞的生长,但减少了它们的迁移. 这一发现影响了对治疗后瘤微环境的理解.

科学领域:

在瘤学瘤学.
手术瘤学手术瘤学
辐射瘤学辐射瘤学

背景情况:

手术和放射治疗是乳腺癌的主要治疗方法.
手术可能会对瘤微环境产生负面影响,可能会促进残留癌细胞的生长.
了解这些微环境变化对于优化治疗策略至关重要.

研究的目的:

为了研究手术内放射治疗 (IORT) 对瘤微环境的影响.
评估IORT治疗患者手术伤口液 (WF) 对乳腺癌细胞生长和运动性的影响.
为了将这些效应与没有接受IORT的患者的伤口液体进行比较.

主要方法:

采集的手术前血清 (PS) 和伤口液体 (WF) 从乳腺癌患者接受手术或没有IORT.
将净化PS和WF应用于MCF-7乳腺癌细胞培养物.
利用MTT和伤愈合测试来测量细胞生长和移动性.

主要成果:

与非IORT患者的手术前血清 (PS) 或WF相比,接受IORT治疗的患者的伤口液 (WF+) 显著增加了MCF-7细胞生长.
无论是WF+还是WF-都减少了癌细胞迁移,而WF+显示出更明显的抑制作用.
这些发现表明IORT对瘤微环境的差异性影响.

结论:

经过手术和IORT治疗的乳腺癌患者的伤口液促进了瘤细胞的增殖.
这种伤口液还会损害瘤细胞迁移,表明它对瘤行为的复杂影响.
需要进一步的研究来阐明涉及的具体机制.

关键词:

乳腺癌乳腺癌乳腺癌在手术内进行放射治疗.新生体新生体新生体放射疗法,辅助剂疗法,辅助剂瘤微环境瘤微环境

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