在局部紫色应用后,患有亚托皮炎的儿童的皮肤微生物群的变化
Joanna Krzysiek1, Joanna Żurawska-Olszewska2, Izabela Szczerba2
1Department of Dermatology, Pediatric and Oncology Dermatology, Medical University of Lodz, Lodz, Poland.
Postepy dermatologii i alergologii
|June 14, 2023
概括
珍紫 (GV) 有效地降低了在儿童的亚托皮炎 (AD) 皮肤病变上的细菌数量. 这种局部治疗可以将葡萄球菌水平降低到健康儿童的水平,而不会损害皮肤生态系统.
科学领域:
- 皮肤病学 皮肤病学
- 微生物学 微生物学
- 儿科 儿科 儿科
背景情况:
- 抗微生物耐药性在治疗与亚托皮性皮肤炎 (AD) 相关的细菌感染方面越来越令人担忧.
- 局部用紫 (GV) 是一种潜在的替代治疗方法,因为它已知的抗菌和抗真菌特性.
研究的目的:
- 评估2%水性紫 (GV) 在改变AD儿童病变皮肤的微生物组成方面的疗效.
- 为了比较AD病变皮肤的微生物概况与GV治疗前后的健康对照.
主要方法:
- 一项涉及30名患有AD的儿童和30名2-12岁的健康对照者的研究.
- 使用CHROMagar介质的皮肤印记板,在2%的水性GV应用前和后3天从受伤皮肤收集样本.
- 细菌殖民地通过Phoenix BD测试系统进行了量化和鉴定.
主要成果:
- 在AD患者和GV应用后对照组中观察到总体细菌数量的统计显著减少 (p <0.05).
- 在GV治疗后,在阿尔茨海默病患者中观察到Staphylococcus物种的显著减少,包括S. aureus.
- 在治疗后,阿兹海默症患者的葡萄球菌水平与治疗前健康对照组的水平相当 (p = 1.000).
结论:
- 珍紫 (GV) 治疗有效地减少了对亚托皮炎病变的过度细菌负载.
- GV的应用使湿疹皮肤上的细菌数量正常化,达到与健康个体相似的水平.
- 该研究表明,GV是一种安全的局部选择,不会破坏皮肤表面生态系统.
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