二甲相关的痴呆风险和原发病偏差通过使用电子医疗记录的多个内核学习揭示
Takashi Hayakawa1,2, Takuya Nagashima1,2, Hayato Akimoto1,2
1Division of Pharmacology, Department of Biomedical Sciences, Nihon University School of Medicine, Tokyo, Japan.
Digital health
|June 14, 2023
概括
这项研究表明,使用二胺和痴呆风险之间的观察到的关联可能受到反向因果关系和混因素的影响,特别是短效二胺. 经过调整后,长期使用没有显示出明显的痴呆风险关联.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 流行病学 流行病学
背景情况:
- 类药物在痴呆症发展中的作用仍然存在争议.
- 以前的研究表明存在潜在的联系,但存在方法上的局限性.
研究的目的:
- 为了研究二二类药物 (周期,剂量) 和痴呆症风险之间的非线性关系.
- 探索潜在疾病 (失眠,焦虑,情感障碍) 对痴呆风险的影响.
- 澄清使用二胺和发病性痴呆症之间的关联,考虑混因素.
主要方法:
- 使用多个内核学习扩展经典危险模型.
- 应用调整的最大概率估计与十倍的交叉验证.
- 利用了40岁以上的8160名患者的回顾性电子病历数据.
主要成果:
- 检测到与失眠/焦虑的持续时间和短效二二二二二二二二二二二二二二二二二二二三二二二三二二三二二三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三三
- 在对混因子进行非线性调整后,在长期使用二甲时没有发现明显的痴呆风险关联.
- 非线性风险变化表明了潜在的反向因果关系和混偏差.
结论:
- 观察到的关联可能受到反向因果关系和混的影响,这可能解释了之前的发现.
- 需要重新考虑先前的结果和分析方法.
- 长期使用二甲似乎与痴呆风险的增加没有显著关联.
更多相关视频
09:47Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
Published on: December 15, 2023
1.2K
07:31Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
Published on: May 15, 2020
7.1K
相关概念视频
01:19Sedatives and Hypnotics Drugs: Benzodiazepines
305
Benzodiazepines have both sedative and hypnotic properties. They include compounds such as diazepam (Valium) and alprazolam (Xanax). Structurally, their cores are similar, consisting of the fusion of a benzene ring and a diazepine ring, but they share a common mechanism of action in the central nervous system (CNS).
Benzodiazepines work by enhancing the effects of the inhibitory neurotransmitter GABA. They bind to the GABAA receptor, increasing its affinity for GABA, which opens chloride...
Benzodiazepines work by enhancing the effects of the inhibitory neurotransmitter GABA. They bind to the GABAA receptor, increasing its affinity for GABA, which opens chloride...
305
01:29Anxiolytic Drugs: Benzodiazepines and Buspirone
931
Benzodiazepines are a class of anxiolytic drugs known for their rapid efficacy and high therapeutic-to-lethal dose ratio, but with a potential risk of drug dependence. These drugs are lipophilic, allowing for rapid absorption after oral administration, eventually reaching the central nervous system (CNS). Once in the CNS, benzodiazepines bind to the allosteric site of the GABAA receptor. This binding enhances the inhibitory effects of the neurotransmitter GABA. By doing so, they prevent...
931