空气污染及其对中枢神经系统的不利影响
Ameerah Ruzeeq Alhussaini1, Meaad Refaay Aljabri1, Zeyad T Al-Harbi2
1College of Medicine, Taibah University, Madinah, SAU.
Cureus
|June 14, 2023
概括
空气污染对公共健康构成重大风险,可能导致中枢神经系统 (CNS) 疾病,如中风和多发性硬化症 (MS),通过神经炎症等机制. 进一步的研究对于制定针对这些不良健康影响的预防策略至关重要.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 空气污染是一个主要的全球健康问题,与中枢神经系统 (CNS) 疾病有关.
- 暴露于污染物可以引发慢性脑炎,白质异常和微质激活.
- 这些影响增加了包括自闭症谱系障碍,神经退行性疾病,中风和多发性硬化症 (MS) 在内的疾病的风险.
研究的目的:
- 审查有关空气污染与神经疾病,特别是中风和多发性硬化之间关系的现有文献.
- 综合目前关于空气污染物与中枢神经系统病理联系的途径的证据.
主要方法:
- 在PubMed,EMBASE和Web of Science进行了全面的文献搜索.
- 关键词包括"空气污染"",环境空气污染"",颗粒物"",臭氧"",黑碳"",中风"",脑血管疾病"",多发性硬化症"",神经炎症"和"神经退行".
- 最初确定了128篇文章,其中44篇根据相关性,质量和出版日期进行了详细分析.
主要成果:
- 审查发现了大量的研究,将空气污染与中枢神经系统不良结果联系起来.
- 有证据表明,空气污染有助于神经炎症和神经病理学,增加中风和多发性硬化风险.
- 特定的污染物,如颗粒物,臭氧和黑碳都与此有关.
结论:
- 空气污染是影响中枢神经系统健康的关键环境因素.
- 进一步的研究对于阐明精确的机制和加强证据基础至关重要.
- 调查结果将为制定有针对性的公共卫生干预措施和预防污染相关神经疾病的预防措施提供信息.
相关概念视频
Disorders of the Nervous Tissue
1.4K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
1.4K
Types of Toxins
1.8K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.8K
Toxic Reactions: Overview
1.0K
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
1.0K
Chemical Factors Affecting Respiration Centers
1.2K
Chemical factors such as changing CO2, O2, and H+ levels in arterial blood play a critical role in influencing respiration depth and rates. These variations are detected by chemoreceptors—specialized sensors located in two primary body areas. Central chemoreceptors are found throughout the brain stem, including the ventrolateral medulla, while peripheral chemoreceptors are located in the aortic arch and carotid arteries.
CO2 has a potent influence on respiration and is strictly regulated....
CO2 has a potent influence on respiration and is strictly regulated....
1.2K
Local Anesthetics: Adverse Effects
458
While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
458
Other Pulmonary Disorders
876
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
876


