参与预后的关键基因在肺腺癌中通过综合生物信息学分析被确定
Hao Song1, Junfeng Wu1, Wang Liu2
1The Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China.
Heliyon
|June 14, 2023
概括
环素B2 (CCNB2) 和CDC20是肺腺癌 (LUAD) 的关键基因. 它们的高表达与预后不佳相关,并影响免疫细胞透,为新的癌症治疗提供了潜力.
科学领域:
- 在瘤学瘤学.
- 生物信息学是一种生物信息学.
- 分子生物学分子生物学
背景情况:
- 肺腺癌 (LUAD) 是癌症相关死亡的主要原因.
- 确定新的预后生物标志物和治疗点对于改善LUAD患者的治疗结果至关重要.
研究的目的:
- 用生物信息学分析识别LUAD中的核心基因.
- 评估这些核心基因的预后价值.
- 为了研究它们在LUAD中免疫细胞透中的作用.
主要方法:
- 使用了GEO数据库 (GSE11072,GSE32863,GSE43458,GSE115002,GSE116959) 来识别差异表达的基因.
- 使用DAVID,Cytoscape和PPI网络分析来确定核心基因.
- 使用GEPIA,UALCAN,Kaplan-Meier绘图器和TIMER 2.0数据库验证了基因表达,预后价值和免疫透.
主要成果:
- 与正常组织相比,在LUAD组织中,CCNB2和CDC20的调节显著上升.
- 在LUAD患者中,CCNB2和CDC20的更高表达与整体存活率有负相关性.
- 这些基因与细胞循环,卵细胞半转化和免疫细胞透在LUAD中有关.
结论:
- 在LUAD中,CCNB2和CDC20被确定为重要的核心基因.
- 它们作为潜在的预后生物标志物,并参与免疫透.
- 这些发现可能有助于开发用于LUAD的新型抗瘤药物.
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