基于网细胞血红蛋白和肝的度,败血症患者的铁缺乏症:一个前性队列研究
Piotr F Czempik1,2, Agnieszka Wiórek1
1Department of Anaesthesiology and Intensive Care, Faculty of Medical Sciences, Medical University of Silesia, Katowice, Poland.
Archives of medical science : AMS
|June 14, 2023
概括
败血症患者经常有缺铁 (ID) 或缺铁性贫血 (IDA). 网细胞计数可以预测ID/IDA当网细胞血红蛋白等效是不可用的,而肝素是一个糟糕的预测.
科学领域:
- 血液学 血液学 血液学
- 临界护理医学 临界护理医学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 缺铁 (ID) 和缺铁性贫血 (IDA) 在败血症中很常见.
- 传统的铁检测在败血症患者中不可靠.
- 需要新的生物标志物来准确诊断败血症中的ID/IDA.
研究的目的:
- 评估网细胞血红蛋白等效 (Ret-He),网细胞计数 (Rets) 和肝素 (Hep) 对于败血症中的ID/IDA的诊断效用.
- 为了确定ID和IDA在败血症队列中的患病率.
主要方法:
- 用Ret-He和血红蛋白 (Hb) 度来确立ID/IDA的诊断.
- 肝素水平被追溯测量.
- 在预测ID/IDA时,为Rets数和Hep计算了接收器运行特征曲线 (AUROC) 下的面积.
主要成果:
- 在败血症患者中,ID的患病率为7%,IDA为47%.
- 在预测ID/IDA时,AUROC对Rets的数字为0.69.
- 在预测ID/IDA时,肝炎的AUROC为0.62.
结论:
- 近一半的败血症患者表现出缺铁或缺铁性贫血.
- 当Ret-He无法访问时,网细胞计数可以作为ID/IDA的预测指标.
- 赫普西丁在败血症中显示出有限的价值作为IDA的预测因素.
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