对成年人单相和多相急性传播性脑膜炎的临床比较分析
Wei-Zhou Zang1, Hong Yang1,2, Dan Li1
1Department of Neurology, Henan Provincial People's Hospital, Zhengzhou, China.
Archives of medical science : AMS
|June 14, 2023
概括
患有急性传播性脑膜炎 (ADEM) 的成年人表现出各种症状,有些病例是多相的. 确定ADEM复发的预测因素对于更好的患者结果至关重要.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 临床医学 临床医学
背景情况:
- 急性扩散性脑膜炎 (ADEM) 是中枢神经系统的免疫媒介性炎症性脱髓化疾病.
- 虽然通常被认为是一种单相性疾病,但ADEM的复发性或多相性形式可能会发生,特别是在成年人中.
研究的目的:
- 在成年患者中研究ADEM的临床特征.
- 确定与成人ADEM病例复发相关的潜在预后因素.
主要方法:
- 对56名被诊断患有ADEM的成年患者的回顾性分析.
- 评估流行病学数据,临床症状,实验室发现,MRI结果,治疗和结果.
- 使用奇平方和曼-惠特尼U测试进行统计分析,以确定显著因素.
主要成果:
- 常见的症状包括四肢/异常感觉 (73%),意识障碍 (52%) 和自主功能障碍 (43%).
- 在13名患者中观察到多相ADEM,52%的患者有先前的激励因素.
- 大脑脊髓液显示出突出的炎症变化,MRI显示出特有的脱髓化病变.
结论:
- 成人ADEM具有复杂和多样化的临床特征,包括多相疗程.
- 潜在的ADEM复发的临床预测因素可能存在于最初的发作,需要进一步调查.
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