天然和类似自然的多化合物:体外抗氧化活性和治疗应用的潜力
Jasmina Brboric1, Aleksandra Klisic2, Jelena Kotur-Stevuljevic1
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade, Serbia, Serbia.
Archives of medical science : AMS
|June 14, 2023
概括
这项研究选了36种化合物的抗氧化活性. 脱素衍生物显示出最强的抗氧化剂和最低的抗氧化剂效应,表明潜在的治疗应用.
科学领域:
- 生物化学 生物化学
- 自然产品 化学 化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 是一种多样化的化合物,以其抗氧化特性而闻名.
- 自然和合成,包括单体和二体,正在研究它们的生物活性.
- 了解化合物的抗氧化和抗氧化平衡对于治疗开发至关重要.
研究的目的:
- 选天然和与自然相似的单体及其C2对称二次体的抗氧化和抗氧化活性.
- 为了确定具有强大的抗氧化作用和最小的抗氧化潜力的特定化合物.
- 为了评估对化合物中强有力的抗氧化活性负责的药.
主要方法:
- 在体外评估36种不同的化合物的抗氧化特性.
- 利用各种氧化还原试验来测量总氧化潜力 (TOP),总抗氧化能力 (TAC) 和亲氧化-抗氧化剂平衡 (PAB).
- 评估的SH组总含量 (SHG) 和计算的亲氧化分数,抗氧化分数和氧化分数,用Trolox作为阳性对照.
主要成果:
- 在36种化合物中,有6种化合物在人体血清中表现出显著的抗氧化活性.
- 脱甘衍生物 (化合物6和12) 在所有测试的醇中表现出最高的抗氧化活性.
- 四种化合物表现出极弱的抗氧化活性,而特罗洛克斯的活性在强抗氧化剂和弱抗氧化剂之间.
结论:
- 精选的脱辛格龙衍生物成为进一步生物评估的有希望的候选物.
- 这些化合物可以作为合成新型多分子的有价值的前体.
- 这些发现表明,特定的脱水基龙衍生物具有潜在的治疗应用.
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