早期识别超重血糖症可能会改善2型糖尿病的临床结果
Anand Chockalingam1,2, Pandiyan Natarajan3, Smrita Dorairajan4
1Division of Cardiovascular Medicine, University of Missouri, Columbia, MO, USA.
TouchREVIEWS in endocrinology
|June 14, 2023
概括
尽管取得了进展,但2型糖尿病的结果已经停滞不前. 将严重肥胖转变为超重高血糖症,由过度营养驱动,通过改变生活方式,为缓解提供了一条通往缓解的道路.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 公共卫生 公共卫生
背景情况:
- 糖尿病是导致死亡的主要原因,而2型糖尿病的结果在上个世纪几乎没有改善.
- 过度营养和生活方式因素,而不仅仅是胰岛素耐药性或遗传,正在推动糖尿病患病率的急剧上升.
- 严重肥胖 (BMI>35 kg/m2),年轻年龄和饮食不良可能表明可逆β细胞功能障碍.
研究的目的:
- 审查糖尿病的全球趋势,并通过重新定义这种情况来探索改善结果的潜力.
- 倡导改变对糖尿病缓解的看法,资金和个人参与.
- 突出营养过剩和肥胖在糖尿病流行病中的核心作用.
主要方法:
- 关于糖尿病趋势,病理生理学和治疗结果的文献综述.
- 分析生活方式,饮食和肥胖对糖尿病发展和进展的影响.
- 综合证据支持重构对严重肥胖个体2型糖尿病的理解.
主要成果:
- 过度营养和严重肥胖被确定为2型糖尿病的主要驱动因素,超过了胰岛素抵抗和遗传学的影响.
- 与2型糖尿病相关的高血糖和末端器官损伤在许多情况下可以通过饮食和减肥来逆转.
- 将严重肥胖的2型糖尿病重新定义为"超重血糖症"可以鼓励改变生活方式并促进缓解.
结论:
- 要解决全球糖尿病危机,需要改变范式,重点关注过度营养和肥胖.
- 将糖尿病重新定义为"超重高血糖症"可以促进社会,政府和个人对更健康的生活方式和缓解的承诺.
- 通过针对饮食和体重管理的有针对性的干预措施,可以实现改善糖尿病并发症的结果和潜在逆转.
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