评估两个事件时间之间的关联,并对观察进行信息审查
Dongdong Li1, X Joan Hu2, Rui Wang1,3
1Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA.
Journal of the American Statistical Association
|June 14, 2023
概括
这项研究引入了一种新的统计方法来分析两个事件时间之间的关联,即使有信息审查. 该方法有效地估计了对生存数据的共变量效应,这对医学研究至关重要.
科学领域:
- 生物统计学 生物统计学
- 生存分析的分析.
- 统计建模 统计建模
背景情况:
- 分析两个事件时间之间的关联是复杂的,特别是信息审查.
- 在信息审查下评估协同变量对关联的影响的现有方法是有限的.
研究的目的:
- 开发一种新的半参数统计框架,用于评估两个事件时间之间的关联,并对其进行信息审查.
- 灵活地模拟边际和联合事件时间分布上的共变量效应.
主要方法:
- 使用嵌套的copula函数,将事件时间和信息审查时间的联合分布连接起来.
- 在半参数双变量事件时间模型中,用于共变量效应的灵活函数形式.
- 开发一种基于伪概率的推理程序,同时估计关联参数,边际生存函数和共变量效应.
主要成果:
- 拟议的方法始终估计了依赖于共变量的边际生存函数.
- 模拟研究证明了估计者的有限样本性能.
- 该方法提供了一种可靠的方式来评估复杂的生存数据中的共变量效应.
结论:
- 开发的统计方法提供了一种灵活和有效的方法,用于分析具有信息审查的双变事件时间.
- 这一框架对于在临床研究中了解疾病进展和治疗效果有价值,例如分析的乳腺癌存活率数据.
- 伪概率推理程序在实现和分析方面非常实用.
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