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高流量和低流量雾化盐水对气道水分和粘膜细胞运输的影响
Susyn Kelly1, Matthew Valentine2, Wei Hang Chua3
1Fisher & Paykel Healthcare, Auckland, New Zealand.
ERJ open research
|June 14, 2023
概括
雾化盐水,异性0.9%和高性7.0%,在非侵入性呼吸辅助过程中有效增强粘膜细胞运输. 然而,高血压盐水在频繁使用时可能会对纤毛功能产生负面影响.
科学领域:
- 呼吸系统生理学 呼吸系统生理学
- 肺部药物输送 肺部药物输送
背景情况:
- 雾化药物和盐水越来越多地用于非侵入性呼吸支持,如鼻高流疗法.
- 了解不同度的盐水对粘膜运输的水分效应对于优化呼吸系统护理至关重要.
研究的目的:
- 为了在体外模型中比较雾化0.9%的同位素和7.0%的高位素盐水对粘膜运输的水分效应.
- 评估高流量与低流量交付对这些效应的影响.
主要方法:
- 一个体外研究使用10只绵羊的气管在 perfused 器官浴.
- 雾化0.9%和7.0%的盐水通过加热,加湿的空气在高 (20 L·min-1) 和低 (7 L·min-1) 流速下输送.
- 测量包括气道表面液体高度,粘液运输速度,乳毛跳动频率和表面温度.
主要成果:
- 这两种盐酸度都显著增加了气道表面液体高度和粘液运输速度.
- 超性7.0%盐溶液显著增加了气道表面液体高度,比同性0.9%盐溶液在低流速和高流速时更高.
- 乳头跳动频率在0.9%的盐水中保持不变,但在7.0%的盐水中降低,特别是在低流量时.
结论:
- 雾化异和高盐水显著刺激粘膜细胞运输.
- 与低流量输送相比,高流量输送没有显示显著不同的水化效应.
- 高血压盐水抑制纤毛动的作用表明,在频繁服用时,可能会对呼吸道表面产生负面影响.
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