短波红外扩散光学可穿戴探头用于使用深度学习量化乳液幻体中的水和脂质含量
Samuel S Spink1, Anahita Pilvar2, Lina Lin Wei1
1Boston University, Department of Biomedical Engineering, Boston, Massachusetts, United States.
Journal of biomedical optics
|June 14, 2023
概括
这项研究开发了一种可穿戴的短波红外 (SWIR) 探头,用于准确,无标签地测量组织中的水和脂质含量. 这项技术有可能在家中和诊所进行非侵入性健康监测.
科学领域:
- 生物医学光学 生物医学光学
- 医疗器械 医疗器械
- 频谱学是一种光谱学.
背景情况:
- 短波红外 (SWIR) 波长为无标签组织分析提供了独特的优势,这是由于特定的染色体吸收和低分散.
- 精确量化水和脂质对于监测水分,身体成分和癌症等疾病至关重要.
- 目前的护理点或可穿戴设备无法利用SWIR技术,限制了其临床转化.
研究的目的:
- 设计和制造一个可穿戴的扩散光学探头,利用SWIR波长.
- 为了准确量化生物组织中的水和脂质含量.
主要方法:
- 模拟将SWIR与近红外 (NIR) 波长进行了比较,以获得理论上的优势.
- 一个可穿戴的探测器用980nm,1200nm和1300nm的LED和四个源探测器分离构建.
- 在体外验证中使用了不同水和脂质度的乳液幻影,用深度神经网络反向模型进行分析.
主要成果:
- 与NIR相比,SWIR模拟显示水和脂质提取错误减少.
- SWIR探测器显示了良好的信号噪声比和低漂移,源探测器距离高达10毫米.
- 在体外定量测试中,误差很低:水为11.4%,脂质为10.5%.
结论:
- 开发的扩散光学SWIR探头在体外准确量化水和脂质含量.
- 这种可穿戴的SWIR探测器显示了未来人体体内体验研究和临床应用的前景.
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