脂肪组织分布对子宫内膜癌的影响:系统性审查
Anouk A S van den Bosch1, Johanna M A Pijnenborg2, Andrea Romano1
1Department of Obstetrics and Gynecology, GROW-School for Oncology and Reproduction, Maastricht University Medical Centre, Maastricht, Netherlands.
Frontiers in oncology
|June 14, 2023
概括
脂肪组织分布显著影响子宫内膜癌 (EC) 的特征和患者的预后. 内脏脂肪组织增加与EC患者的生存结果较差有关.
科学领域:
- 妇科瘤学 妇科瘤学
- 内分泌学 在内分泌学.
- 代谢性疾病 代谢性疾病
背景情况:
- 子宫内膜癌 (EC) 发病率正在上升,与增加的预期寿命和肥胖症有关.
- 脂肪组织 (AT) 作为内分泌器官起作用,其分布可能会影响疾病的发展和预后.
- 关于AT分销对欧洲共同体发展和成果的具体影响尚不清楚.
研究的目的:
- 系统地审查和确定AT分布和EC患者/疾病特征之间的关联.
- 研究AT分布与EC患者预后之间的关系.
主要方法:
- 在Medline,MEDLINE EMBASE和Cochrane图书馆进行系统的文献搜索.
- 包括EC患者的回顾性研究,区分内脏和皮下AT区.
- 对结果指标和AT分布进行的相关分析.
主要成果:
- 包括11项追溯性研究,分析了内脏和皮下AT区.
- AT分布与肥胖度,组织学亚型,淋巴结转移和性类固醇水平有显著的相关性.
- 内脂肪组织 (VAT) 体积增加与较差的整体存活率,无进展存活率和疾病特异性存活率显著相关.
结论:
- 在AT分布和EC预后,BMI,性类固醇水平和疾病特征之间存在显著的相关性.
- 进一步的精心设计,前性,大规模的研究是必要的,以阐明这些关系的预测和治疗.
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