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化疗对肝细胞癌的影响:一项回顾性研究

Masahide Isowa¹, Reo Hamaguchi¹, Ryoko Narui¹

¹Japanese Society on Inflammation and Metabolism in Cancer, Nakagyo-ku, Kyoto, Japan.

Frontiers in oncology

|June 14, 2023

概括

与标准治疗相结合的化疗法可能会改善肝细胞癌 (HCC) 患者的治疗结果. 保持尿液pH值为7.0或更高与HCC患者的整体存活时间显著延长有关.

科学领域:

在瘤学瘤学.
临床医学临床医学
生物化学生化学

背景情况:

尽管治疗方面取得了进展,肝细胞癌 (HCC) 的复发仍然是一个挑战.
目前的HCC疗法没有显著延长患者的存活时间.
目前正在探索化疗法作为一种补充治疗,以改善HCC患者的预后.

研究的目的:

评估用化疗法治疗的HCC患者的临床结果.
为了研究尿液pH和HCC患者接受化治疗的整体存活率之间的关联.

主要方法:

从2013年到2020年在卡拉苏马瓦达诊所接受治疗的HCC患者的回顾性分析.
从诊断和 alkalization 治疗开始的整体存活时间 (OS) 的比较.
评估平均尿液pH值作为瘤微环境pH值的替代品及其与OS的相关性.

主要成果:

总共分析了29名HCC患者 (23名男性,6名女性).
从 alkalization 疗法开始,与pH < 7.0 (15.4个月) 患者相比,平均尿液pH ≥ 7.0 (未达到) 的患者的中位寿命显著更长.
尿液pH值≥7.0与改善的生存结果有关.

结论:

化疗法,当与标准治疗相结合时,可能为HCC患者提供更好的结果.
在化疗法后尿液pH值升高 (≥7.0) 似乎是HCC的积极预后指标.
需要进一步的研究来证实化疗法在HCC治疗中的作用.

关键词:

化疗法是一种化疗法.癌症的代谢癌症的代谢肝细胞癌是肝细胞癌.瘤微环境是一个微环境.尿液pH值尿液pH值

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