基于纳米纤维素的水凝用于药物输送
Yusen Ai1, Zhongxin Lin1, Wenqi Zhao2
1State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P. R. China.
Journal of materials chemistry. B
|June 14, 2023
概括
纳米纤维素水凝由于其生物相容性和可调性特性,提供了有前途的药物递送系统 (DDS). 本综述详细介绍了他们为高级DDS应用程序的准备,形式和性能.
科学领域:
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
- 聚合物化学 聚合物化学
背景情况:
- 水凝是药物递送系统 (DDS) 的关键3D聚合物网络,由于其多孔性和水友性.
- 临床DDS要求包括低毒性,高生物相容性,向性,受控释放和高药物负载.
- 纳米纤维素,包括纤维素纳米晶体 (CNC) 和纤维素纳米纤维素 (CNF),是基于水凝的DDS的一个有希望的生物材料.
研究的目的:
- 为提供纳米纤维素基水凝用于药物输送的全面审查.
- 讨论制备方法,载体形式和药物输送参数.
- 确定这些先进的DDS的机会,挑战和未来的研究方向.
主要方法:
- 对纳米纤维素水凝制剂的物理和化学交联方法的审查.
- 对各种纳米纤维素水凝载体形式 (颗粒,薄膜,可注射,可喷) 的分析.
- 检查药物加载效率,释放动力学和刺激反应.
主要成果:
- 纳米纤维素水凝为DDS提供高表面积,生物相容性和可降解性.
- 多种不同的制备技术使得适合特定药物输送需求的水凝特性得以量身定制.
- 纳米纤维素水凝证明了有效的药物加载和受控释放的潜力.
结论:
- 基于纳米纤维素的水凝代表了先进的药物输送系统的多功能平台.
- 需要对应用,挑战和优化进行进一步的研究,才能充分发挥其潜力.
- 未来的方向包括多功能化和探索新的DDS配方.
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