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中枢神经系统的真菌菌病是由Octodon degus中的Mycobacterium genavense引起的
Tatsuhito Ii1, James K Chambers1, Mizuho Uneyama1
1The University of Tokyo, Tokyo, Japan.
Veterinary pathology
|June 14, 2023
概括
德格斯 (*Octodon degus*) 可能易受中枢神经系统感染. 这项研究确定了 *Mycobacterium genavense * 作为 degus 中的神经和呼吸系统疾病的原因.
科学领域:
- 兽医病理学 兽医病理学
- 微生物学 微生物学
- 神经学 神经学
背景情况:
- 德格斯 (*Octodon degus*) 越来越多地被用作实验动物.
- 在养殖设施的德格斯中观察到神经和呼吸系统疾病.
研究的目的:
- 调查神经和呼吸系统疾病以及 degus.死亡的原因.
- 为了确定负责中枢神经系统 (CNS) 病理的致病原体在受影响的 degus.
主要方法:
- 尸检和组织学检查9个受影响的 degus.
- 通过免疫组织化学识别酸敏细菌和*Mycobacterium tuberculosis*抗原.
- 使用聚合酶链反应 (PCR) 和DNA测序对细菌进行分子鉴定.
主要成果:
- 组织学发现包括脊髓缩,粒状髓炎,大脑缩和脑炎在受影响的脑部.
- 在所有病例的脊髓,大脑和肺部检测到酸性细菌和*Mycobacterium tuberculosis*抗原.
- 在9个病例中,DNA测序证实了8个病例中存在Mycobacterium genavense.
结论:
- *Mycobacterium genavense* 感染可以导致严重的中枢神经系统疾病.
- 德格斯对*M. genavense*易感,这突出了它们在研究中的使用的潜在挑战.
- 这项研究确定了在这种动物模型中引起神经疾病的新型病原体.
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