痛风患者左心室结构和功能的变化:基于三维斑点跟踪回声心脏图的研究
Yuanyuan Meng1, Leiyuan Ma2, Tingyu Zong1
1Department of Cardiac Ultrasound, The Affiliated Hospital of Qingdao University, Qingdao, China.
Journal of clinical ultrasound : JCU
|June 14, 2023
概括
痛风患者表现出亚临床的左心室变形和重塑,即使射出分数正常. 三维斑点追踪回声心力学 (3D-STE) 检测到这些早期心脏变化在痛风患者.
科学领域:
- 心脏病学 心脏病学
- 医疗成像医学成像
- 类风湿病学 类风湿病学
背景情况:
- 痛风与心血管疾病风险增加有关.
- 微妙的心肌功能障碍可以在明显的心脏事件之前发生.
- 三维斑点追踪回声心力学 (3D-STE) 提供了对心脏异常的敏感检测.
研究的目的:
- 在患有痛风的患者中使用3D-STE.评估左心室 (LV) 功能.
- 在痛风患者中识别心脏功能障碍的早期迹象.
- 评估3D-STE在检测与痛风相关的亚临床心脏变化的实用性.
主要方法:
- 参与了80名受试者:40名患有痛风和40名健康对照.
- 使用3D-STE分析3D全体积数据集的动态图像.
- 测量参数包括全球纵向应变 (GLS),全球环形应变 (GCS),全球辐射应变 (GRS),Twist和缩失调指数 (SDI).
主要成果:
- 痛风患者表现出左心室重塑和减弱的透静功能 (减少了Em,增加了E/Em,更大的LAVI).
- 与对照组相比,在痛风患者中观察到明显较低的峰值GLS,GCS,GRS和Twist.
- 痛风患者的SDI增加表明缩同步受损,GLS显示高诊断准确度 (AUC:0.93).
结论:
- 患有痛风的患者可能具有亚临床的左心室变形和结构重塑,尽管正常的射出分数.
- 3D-STE有效检测痛风患者的早期心脏功能障碍.
- 这些发现强调了心脏监测对患有痛风的人的重要性.
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