在接受crizotinib治疗的非小细胞肺癌患者中,估计的淋巴膜过率下降
Yakup Iriagac1, Eyyup Cavdar1, Kubilay Karaboyun1
1Department of Medical Oncology, Faculty of Medicine, Tekirdag Namik Kemal University, Tekirdag, Turkey.
Journal of cancer research and therapeutics
|June 14, 2023
概括
治疗非小细胞肺癌的克里佐替尼可能会导致功能暂时下降,以估计的膜过率 (eGFR) 来衡量. 在停止服用药物后,这种eGFR的减少是可逆的.
科学领域:
- 在瘤学瘤学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药理学 药理学是指药理学的学科.
背景情况:
- 克里佐替尼 (crizotinib) 是一种用于非小细胞肺癌 (NSCLC) 的氨酸激酶抑制剂.
- 关于crizotinib对功能的影响存在不确定性.
- 这项研究调查了crizotinib对NSCLC患者功能不良影响.
研究的目的:
- 为了评估crizotinib对NSCLC患者功能的影响.
- 为了记录对脏参数的潜在不良影响.
- 评估任何观察到的功能变化的可逆性.
主要方法:
- 使用慢性病流行病学协作 (CKD-EPI) 方程计算估计的淋巴球过率 (eGFR).
- 基于肌素的eGFR值在治疗前和治疗期间每月间隔进行比较.
- 采用配对样本t测试和卡普兰-梅尔生存分析.
主要成果:
- 分析了接受crizotinib的26名NSCLC患者.
- 在crizotinib治疗的第一个月后,观察到EGFR显著降低 (P < 0.001).
- 在停止治疗后,eGFR的下降是可逆的,与治疗前水平相比没有显著差异 (P = 0.100).
结论:
- 克里佐替尼治疗与功能可逆性下降有关.
- 观察到的下降可能是由于脏炎症或伪减少从改变的肌素分泌.
- 基于非肌素的eGFR计算方法可以在接受crizotinib的患者中提供更准确的功能评估.
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