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在常见的耳鼻喉科手术过程中,比较人类和动物组织中的气溶生成
Christopher Nielson1, Kerry Kelly2, Reuben Attah2
1Division of Otolaryngology-Head and Neck Surgery, University of Utah School of Medicine, Salt Lake City, Utah, USA.
概括
常见的耳鼻喉科手术技术,包括钻孔和电,在人体和仓鼠组织中产生类似的气溶颗粒趋势. 仓鼠组织通常产生更高的气溶度,但观察到一些统计学上显著的差异.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 手术气溶生成器手术气溶生成器
- 生物医学工程 生物医学工程
背景情况:
- 在手术过程中产生的气溶颗粒对医疗保健专业人员构成潜在风险.
- 了解动物模型与人体组织的可比性对于临床前研究至关重要.
研究的目的:
- 为了比较常见的耳鼻喉科手术技术中人类和仓鼠组织之间的气溶颗粒生成.
- 评估颗粒大小和度的相似性和差异.
主要方法:
- 量化实验研究是在大学实验室进行的.
- 在人类和仓鼠组织上进行了钻探,电和合.
- 使用扫描移动性粒子测量仪和气溶粒子测量仪 (SMPS-APS) 和GRIMM气溶粒子光谱仪测量了颗粒大小和度.
主要成果:
- 所有程序显示,与基线相比,气溶的度至少增加了2倍.
- 人类和仓鼠组织表现出类似的趋势和气溶度的大小.
- 仓鼠组织通常产生更高的气溶度,在某些情况下有统计学上显著的差异.
结论:
- 耳鼻喉科的气溶生成程序显示了人类和仓鼠组织之间的颗粒度和大小的可比趋势.
- 在人类和仓鼠组织之间,在气溶度和颗粒大小上发现了一些统计学上显著的差异.
- 需要进一步的研究来确定这些观察到的差异的临床意义.
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