系统性炎症反应指数 (SIRI) 的预测值,用于复杂冠状动脉疾病发生在患有心痛等效症状的患者中
Tomasz Urbanowicz1, Michał Michalak2, Anna Komosa3
1Cardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, Poznan, Poland. tomasz.urbanowicz@skpp.edu.pl.
Cardiology journal
|June 14, 2023
概括
系统性炎症反应指数 (SIRI),一种简单的血液测试,可以帮助预测冠状动脉疾病 (CAD) 在患有胸痛症状的患者. 超过1.22的SIRI表明显著冠状动脉疾病的可能性更高.
科学领域:
- 心脏病学 心脏病学
- 血液学 血液学 血液学
- 炎症研究 炎症研究
背景情况:
- 动脉样性心血管疾病是全球主要的死亡原因.
- 炎症过程是冠状动脉斑块发展和进展的关键驱动因素.
- 血液学指数,如系统性炎症反应指数 (SIRI),提供潜在的炎症标志物.
研究的目的:
- 评估系统性炎症反应指数 (SIRI) 在冠状动脉疾病 (CAD) 发生中的预测作用.
- 评估SIRI作为诊断标志物在患有心痛等效症状的患者中的有用性.
主要方法:
- 对256名患者 (174名男性,82名女性) 进行了回顾性分析,这些患者的症状相当于胸痛.
- 使用人口统计数据和血细胞参数开发CAD的预测模型.
- 后勤回归多变量分析以确定重要的预测因素.
主要成果:
- 男性的性别,年龄,体重指数和吸烟是CAD的重要人口预测因素.
- 系统性炎症反应指数 (SIRI) 和红细胞分布宽度 (RDW) 成为重要的实验室预测指标.
- 在预测CAD时,SIRI显示了显著的几率比率 (OR:5.52).
结论:
- 系统性炎症反应指数 (SIRI) 是一种有价值的血液学指数,用于诊断患有心痛等效症状的患者的CAD.
- 一个SIRI值为1.22与单个和复杂的冠状动脉疾病的更高概率有关 (AUC:0.725,p <0.001).
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