撤回:纳比隆作为抗药在因耐火性胃肠道疾病引起的持续吐中有用
Cristina Olmedo Moreno1, Richard Holman2, Manni Naghibi2
1Gastroenterology and Hepathology, Hospital Universitario 12 de Octubre, ESPAÑA.
Revista espanola de enfermedades digestivas
|June 14, 2023
概括
纳比龙是一种合成大麻素,在耐性胃肠不运动 (GID) 吐患者中显示出适度的症状改善. 然而,超过一半的人经历了副作用,建议谨慎使用.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 由于胃肠道动力障碍 (GID) 的耐药性吐带来了重大治疗挑战.
- 纳比龙是一种合成大麻素,已被批准用于化疗引起的吐,但其在GID中的有效性尚未报告.
研究的目的:
- 评估纳比隆在GID引起的耐火性吐患者中的有用性和副作用.
- 评估nabilone作为难以治疗的GID相关恶心和吐的治疗选择的潜力.
主要方法:
- 七名在2017年1月至2022年9月期间为GID吐处方纳比隆的患者的回顾性评估.
- 收集的数据包括患者人口统计学,并发症,先前治疗,营养支持,纳比隆剂量,治疗持续时间,症状改善和副作用.
主要成果:
- 纳比隆被处方给了七名患者 (72%为女性,中位数年龄为25岁) 患有各种GID原因,包括胃和肠道动力障碍.
- 43%的患者报告说,纳比隆治疗症状有所改善,57%的患者出现了头痛,嗜睡或幻觉等副作用.
- 每天两次超过1毫克的剂量没有显示出额外的益处,并且与副作用的增加有关.
结论:
- 纳比龙可以为近一半耐火性GID吐患者提供暂时的症状缓解.
- 副作用很常见 (超过50%),需要仔细考虑风险与益处.
- 较低剂量 (每天两次1毫克) 似乎更好地耐受,并且可能与较高剂量一样有效.
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