折射误差对圆柱状细胞结构-功能与血管密度-功能关系在开放角度眼镜的影响
Yoshinobu Emoto1, Gábor Hollό2,3, Yoshiyuki Kita1
1Department of Ophthalmology, Kyorin University School of Medicine, Tokyo, Japan.
Journal of glaucoma
|June 14, 2023
概括
在日本开放角眼 (OAG) 患者中,环囊血管密度 (cpVD) 与视野参数 (MD和VFI) 的相关性比视网膜神经纤维层厚度 (RNFLT) 更强. 这种关系在所有折射误差类别中保持,包括高近视.
科学领域:
- 眼科医生 眼科 眼科
- 玻璃眼研究研究 玻璃眼研究
- 光学一致性断层扫描成像成像
背景情况:
- 开角光眼 (OAG) 是不可逆转失明的主要原因.
- 评估结构和功能参数之间的关系对于理解青光眼的进展至关重要.
- 折射误差可以影响眼睛结构和视野的测量.
研究的目的:
- 为了研究折射误差如何影响围状视网膜神经纤维层厚度 (cpRNFLT) 和围状血管密度 (cpVD) 与日本OAG眼中的视野参数之间的关联.
- 为了将cpRNFLT和cpVD之间的相关性强度与不同折射误差组的视野指数进行比较.
主要方法:
- 一项涉及81名日本OAG患者的横截面研究,其折射误差范围从+3.0到-9.0 D.
- 使用Cirrus HD 5000-AngioPlex OCT获得了360度cpRNFLT和cpVD测量结果.
- 30-2 汉弗雷视野测试进行,以评估平均偏差 (MD) 和视野指数 (VFI).
主要成果:
- 在总人口中,视野参数 (MD,VFI) 和cpRNFLT和cpVD之间观察到强烈的相关性,cpVD显示较高的相关系数 (cpVD的r=0.722与cpRNFLT的r=0.532).
- cpRNFLT和视野参数之间的相关性仅在输出/超视和中度近视组中具有意义.
- 在所有折射子组,包括高近视 (r值从0.548到0.841) 中,一致发现cpVD和视野参数之间的显著和强相关性.
结论:
- 圆状血管密度 (cpVD) 与日本OAG眼中的圆状视网膜神经纤维层厚度 (cpRNFLT) 相比,与视野参数 (MD和VFI) 有着强大且系统更强的相关性.
- 在所有折射误差类别中都保留了cpVD和视觉功能之间的强烈关联,特别是包括高近视.
- cpVD可以作为一个有价值的生物标志物来评估眼性视野损失,即使存在显著的折射误差.
相关概念视频
Glaucoma: Overview
633
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
633
Focusing of Light in the Eye
3.0K
Light rays enter the eye through the cornea, a transparent dome-shaped tissue that is the eye's outermost layer. The cornea bends or refracts, light rays traveling to the pupil. The shape of the cornea determines how much of the light is bent and whether the image will be focused correctly on the retina at the back of the eye. Once the light has passed through both refraction layers, it converges into a single focal point onto a small area. This is where photoreceptors start transforming...
3.0K
Open Angle Glaucoma: Treatment
491
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
491
Angle Closure Glaucoma: Treatment
578
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
578
Photoreceptors and Visual Pathways
6.1K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.1K


