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外体细胞在结直肠癌转移中的临床影响

Srestha Ghosh¹, Rajib Dhar², Gauresh Gurudas Shivji³

¹Department of Microbiology, Lady Brabourne College, Kolkata, West Bengal 700017, India.

ACS applied bio materials

|June 14, 2023

概括

外基因组在结直肠癌 (CRC) 检测和治疗方面表现有前途. 这些来自瘤细胞的微小囊泡可以用于液体活检,并有可能开发针对CRC的新诊断和治疗策略.

科学领域:

在瘤学瘤学.
生物化学生化学
分子生物学分子生物学

背景情况:

结肠直肠癌 (CRC) 是一个重大的全球卫生挑战,通常是晚诊断,导致高死亡率.
细胞外囊泡 (EVs),特别是外体,是CRC瘤微环境中的关键信号分子.
瘤细胞衍生外体 (TEXs) 影响CRC进展,包括免疫抑制,血管生成和转移.

研究的目的:

审查外体在结直肠癌发育和进展中的复杂作用.
探索外体对CRC查,诊断和预后生物标志物的影响.
突出目前基于外体的CRC临床试验和未来的研究方向.

主要方法:

文献综述专注于CRC中的外体细胞生物学.
在瘤微环境和CRC进展中的外体功能分析.
在CRC中检查基于外体的液体活检和治疗应用.

主要成果:

外体细胞促进分子运输,改变受体细胞的行为并推动CRC的进展.
循环TEX是CRC液体活检和早期检测的有价值的生物标志物.
基于外体的方法为CRC神经科学提供了一个有前途的途径.

结论:

外基因组在结直肠癌中发挥着多方面的作用,影响其发展,进展和检测潜力.
基于外体的策略代表了CRC生物标志物研究和theranostics的重大进步.
对基于外体的工具的进一步研究对于开发有效的抗结直肠癌策略至关重要.

关键词:

生物标志物生物标志物结肠癌是什么意思结肠癌是什么意思外基因组是外基因组的组成部分.转移转移转移转移治疗药物治疗药物

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