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皮和约欣宾对人类行为在接近-避免冲突中的影响

Kim Fricke^1,2, Nina Alexander³, Thomas Jacobsen⁴

¹Department of Psychology, Medical School Hamburg, Am Kaiserkai 1, 20457, Hamburg, Germany. kim.fricke@medicalschool-hamburg.de.

Psychopharmacology

|June 14, 2023

概括

压力调解剂皮质醇和上腺素没有改变健康个体的接近-避开行为. 观察到行为上的性别差异,可能与丸激素水平有关.

科学领域:

神经科学是一个神经科学.
心理学心理学心理学
行为科学行为科学

背景情况:

方法避免冲突涉及平衡正面和负面刺激.
这种平衡在精神健康障碍中受到破坏,例如焦虑和物质使用障碍.
压力与这些疾病的病因和维持有关,但其对接近-避开行为的确切影响仍然不清楚.

研究的目的:

为了研究皮质醇和诺亚上腺素的药理学操纵对接近避免冲突行为的影响.
检查这些压力媒介如何影响健康个体的基于任务的决策.

主要方法:

一个双盲的,主体之间的设计,有96名健康参与者 (48名女性,48名男性).
用皮,约欣宾,两者,或安慰剂.
在食-掠食不足任务中的表现,以评估接近-避开行为.
对性别和内生性激素水平 (,雌激素) 的分析.

主要成果:

皮质醇和上腺素的药理学操纵被生物压力标志物证实.
没有发现皮或其与约欣宾的相互作用对接近回避行为的显著影响.
约欣宾影响了有风险的食延迟,但整体压力调解者没有复制之前的压力效应.
在行为结果中观察到显著的性别差异,可能与水平有关.

结论:

在这项研究中,主要的压力调解剂 (皮质醇,上腺素) 不足以改变方法避免冲突行为.
研究结果表明,压力对接近避开行为的影响背后的机制可能比预期的更复杂.
需要进一步的研究来阐明精确的途径,通过压力影响冲突情况下的决策.

关键词:

接近行为行为.避免行为是避免行为.皮质醇是一种皮质醇.雌激素是一种雌激素.人类人类人类.皮糖是一种酸盐.诺亚上腺素 (noradrenaline) 是一种上腺素.测试激素测试激素是什么约因胺 (Yohimbine) 是一种

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