患有异常性炎症性肌肉病的患者的高疲劳得分:来自COVAD电子调查的多组比较研究
Silvia Grignaschi1,2, Minchul Kim3, Giovanni Zanframundo1,2
1Department of Internal Medicine and Medical Therapeutics, University of Pavia, Pavia, Lombardia, Italy.
Rheumatology international
|June 14, 2023
概括
患有异常性炎症性肌肉病变 (IIM) 的患者经历显著的疲劳,与其他系统性自身免疫性疾病 (SAID) 相比,比健康人群更高. 女性和白人报告了更高的疲劳水平,表明需要有针对性的护理策略.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 患者报告的结果
背景情况:
- 异形性炎症性肌肉病 (IIM) 是一种使人虚弱的自身免疫性疾病.
- 疲劳是IMM中常见但未被报告的症状,严重影响生活质量.
- 与其他系统性自身免疫疾病 (SAID) 和健康对照 (HCs) 相比,了解 IIM 的疲劳水平对于有效管理至关重要.
研究的目的:
- 通过视觉模拟疲劳量表 (VAS-F) 测量疲劳严重程度,在IIM,非IIMSAID和HC患者中进行比较.
- 确定与这些人群中疲劳得分较高相关的人口因素.
- 为那些经历IIM相关疲劳的人制定量身定制的多学科护理计划.
主要方法:
- 来自国际COVAD电子调查 (2020年12月至2021年8月) 数据的横截面分析.
- 包括6988名接受过至少一剂COVID-19疫苗接种的成年受访者.
- 使用前一周的单项10厘米VAS评估疲劳;用于分析疲劳决定因素的回归模型.
主要成果:
- 患有IIM的患者报告VAS-F得分 (5,IQR 3-7) 比HC (2,IQR 1-5;P < 0.001) 高,得分与非IIMSAIDs (5,IQR 2-7) 相似.
- 与其他人口群体相比,女性和高加索人群的疲劳分数显著更高.
- 在IIM队列中,疾病活动并没有显著改变疲劳得分.
结论:
- 患有IIM的患者经历了相当大的疲劳,类似于其他SAID,比一般人群更大.
- 女性性别和高加索族裔与这种队列中疲劳严重程度的增加有关.
- 这些发现强调了需要分层护理方法来解决疲劳和改善IIM患者的治疗结果.
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