在接受抗真菌预防的血液恶性病患者中侵袭性候群病的流行病学
Margaret E McCort1, Helen Tsai2
1Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA. mnewmanmcc@montefiore.org.
Mycopathologia
|June 14, 2023
概括
血液性恶性瘤患者的侵入性Candida感染正在从Candida albicans转移到非albicans物种. 这种由抗真菌使用和患者因素驱动的变化,会影响这些高风险个体的治疗策略.
科学领域:
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
- 菌类学 菌类学是指菌类学.
背景情况:
- 侵入性Candida感染对患有血液性恶性瘤的患者构成重大风险.
- 不断发展的抗真菌预防,瘤疗法和诊断已经改变了感染格局.
- 尽管取得了进展,但在这种人群中,侵入性角膜炎的发病率和死亡率仍然很高.
研究的目的:
- 描述在血液性恶性瘤患者中侵入性Candida感染的流行病学的变化.
- 为了确定Candida物种分布转变背后的驱动因素.
- 讨论优化患者管理的临床考虑.
主要方法:
- 对血液恶性瘤中侵袭性候群病的当前文献的综述.
- 对流行病学趋势和致病性Candida物种的分析.
- 评估导致物种流行率观察到的转变的因素.
主要成果:
- 非白虫Candida物种现在是侵袭性白病的主要原因.
- 广泛使用醇是推动这一流行病学转变的关键因素.
- 潜在的恶性瘤,治疗强度和机构因素也会产生影响.
结论:
- 转向非白虫Candida的转变需要更新理解和管理策略.
- 优化抗真菌的使用和考虑患者特定因素至关重要.
- 对区域差异和新的治疗方法进行进一步研究是有必要的.
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