睡眠时间与结肠直肠腺瘤之间的关联:越南一例对照研究的发现
Chi Thi-Du Tran1,2,3, Pedram Paragomi4, Mo Thi Tran1
1Vietnam Colorectal Cancer and Polyps Research Program, Vinmec Healthcare System, Hanoi, Vietnam.
概括
睡眠时间短暂增加了越南的结直肠腺瘤风险. 这一发现凸显了充分睡眠对于预防越南人口结肠直肠腺瘤 (CRA) 的重要性.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 睡眠医学 睡眠医学
背景情况:
- 结肠直肠癌 (CRC) 是一个重要的全球健康问题,特别是在越南.
- 结肠直肠腺瘤 (CRA) 是已知的CRC的前体.
- 关于睡眠时间和CRA发育之间的关联,研究有限,特别是在越南人群中.
研究的目的:
- 在越南人群中调查睡眠时间和患结直肠腺瘤 (CRA) 的风险之间的关系.
- 评估睡眠时间是否会影响晚期和未晚期腺瘤的风险.
主要方法:
- 进行了个别匹配的病例控制研究,其中包括870例CRA病例和870例对照.
- 数据来自越南河内的一项大型结肠直肠癌查计划,涉及超过10万名40岁及以上的个人.
- 睡眠时间被分为短 (≤6小时/天),正常 (7-8小时/天) 或长 (>8小时/天),并使用条件逻辑回归分析.
主要成果:
- 短睡眠时间 (≤6小时/天) 与正常睡眠时间 (每天7-8小时) 相比,显著增加CRA风险 [OR,1.48;95% CI,1.12-1.97].
- 这种关联在女性和男性,以及高级和非高级腺瘤中都被观察到.
- 睡眠不足和CRA之间的联系在特定的子组中更为明显,包括身体活跃,没有饮酒史的非肥胖女性,以及患有心脏代谢障碍或肥胖的男性.
结论:
- 睡眠时间短暂与越南人口中晚期和未晚期结直肠腺瘤的患病率较高有关.
- 保持足够的睡眠时间可能在预防和治疗结直肠腺瘤方面发挥关键作用.
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