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Updated: Jul 26, 2025

Examination of Proteins Bound to Nascent DNA in Mammalian Cells Using BrdU-ChIP-Slot-Western Technique
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Examination of Proteins Bound to Nascent DNA in Mammalian Cells Using BrdU-ChIP-Slot-Western Technique

Published on: January 14, 2016

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染色体相关SIN3B保护癌细胞免受基因毒性压力诱导的亡,并决定DNA损伤修复途径的选择

Jorge Morales-Valencia1,2, Coralie Petit1, Alexander Calderon1

  • 1Department of Biochemistry and Molecular Pharmacology, NYU Langone Medical Center, New York, New York.

Molecular cancer research : MCR
|June 14, 2023
PubMed
概括

脚手架蛋白质SIN3B对于DNA修复和基因组完整性至关重要. 它的无活化延迟了双链断裂的分辨率,并使癌细胞对化疗敏感,从而揭示了新的治疗点.

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