986名患者的Aquaporin-4-IgG血清状态的变化:基于实验室的纵向分析
Masoud Majed1, Cristina Valencia Sanchez2, Jeffrey L Bennett3
1Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Annals of neurology
|June 14, 2023
概括
水素-4 (AQP4) -IgG血清阳性通常持续存在. 血清逆转为阴性是不常见的,与年轻的年龄和较低的标位有关,并且可能不能可靠地表明疾病活性降低.
科学领域:
- 神经免疫学 神经免疫学
- 神经学 神经学
- 免疫学 免疫学 免疫学
背景情况:
- 水族-4 (AQP4) -IgG是某些神经系统自身免疫性疾病中的关键生物标志物.
- 了解AQP4-IgG血清状态的变化对于疾病管理和预后至关重要.
研究的目的:
- 调查与水-4 (AQP4) -IgG血清状态变化相关的因素.
- 评估与大量患者队列中的血清状态转移相关的频率和临床因素.
主要方法:
- 来自梅奥诊所神经免疫学实验室 (2007-2021) 的血清学数据的回顾性分析.
- 包括使用基于细胞的测定方法进行至少两次AQP4-IgG测试的患者.
- 多变量逻辑回归用于识别与年龄,性别和初始标位的关联.
主要成果:
- 在933名最初为AQP4-IgG阳性的患者中,11%的血清转化为阴性,通常是短暂的.
- 血清逆转与年轻的年龄 (≤20岁) 和较低的初始标位 (≤1:100) 相关.
- 从阴性转为阳性的血清转换发生在不到1%的患者中,这限制了在血清阴性个体中重复测试的有用性.
结论:
- AQP4-IgG 血清阳性通常是持久的,血清逆转不常见,通常是短暂的.
- 血清逆转不能可靠地反映疾病活动,因为尽管血清状况负面,但仍可能发生攻击.
- 在血清阴性患者中重复检测AQP4-IgG的效用有限,除非临床怀疑很高.
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