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大脑表型建模的临床前景:一篇评论
Abigail S Greene1,2, R Todd Constable1,3,4,5
1Interdepartmental Neuroscience Program, Yale School of Medicine, New Haven, Connecticut.
JAMA psychiatry
|June 14, 2023
概括
使用预测模型将大脑活动与行为联系起来,可以提供精神病学见解,但面临临临床障碍. 跨学科的合作是开发可靠的大脑表型模型以改善诊断和干预的关键.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 计算生物学 计算生物学
背景情况:
- 通过全脑活动了解个体认知和行为差异对于精神疾病研究至关重要.
- 预测建模将大脑活动与表型联系起来是有希望的,但临床应用有限.
- 目前的局限性阻碍了将大脑表型模型转化为实际的精神病学工具.
结论:
- 弥合表型测量开发和大脑表型建模之间的差距可以产生更精确和更有用的模型.
- 这些模型可以阐明表型的宏观神经基础,推进神经科学.
- 针对已识别的神经回路提供了治疗功能障碍的治疗干预的潜力.
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