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Xiaoning Jiang^1,2,3, Feng Wei^1,2,3, Dalin He^1,2,3

¹College of Animal Science and Technology, Shandong Agricultural University, Tai'an, Shandong Province, People's Republic of China.

Avian pathology : journal of the W.V.P.A

|June 14, 2023

概括

鸟类骨病毒 (ARV) 在中国肉中引起严重的关节炎. 这项研究确定了同时流通的低毒性和高毒性ARV菌株,强调了垂直传播在疾病流行中的重要性.

科学领域:

兽医病毒学兽医病毒学
禽类病理学禽类病理学
分子流行病学分子流行病学

背景情况:

中国的家禽生产面临着主要由禽类甲状病毒 (ARV) 引起的 brojler 关节炎/tenosynovitis 的重大挑战.
自2013年以来,观察到高发病率,2020年在安省报告了严重的疫情.

研究的目的:

调查ARV菌株的遗传多样性和病原性,涉及最近在中国肉群中严重关节炎爆发的ARV菌株.
评估垂直传播在商业家禽养殖场ARV流行病学中的潜在作用.

主要方法:

从患病的肉和繁殖群中分离和基因测序ARV.
在小中对孤立的 brojler 菌株进行致病性测试.
对看似健康的肉群体进行血清分析,以检测ARV抗体.
使用未化蛋的死胚胎进行病原体追踪.

主要成果:

成功鉴定和测序了7种致病性 brojler-isolates和2种繁殖者-isolates的ARV.
基因定型揭示了群体内和群体之间不一致的ARV菌株,表明复杂的循环模式.
致病性测试证实了肉分离物在中诱导关节炎的能力.
在未接种疫苗的成年肉群中,ARV抗体的高患病率 (89.66%) 表明不同毒性菌株的共循环.
从死亡胚胎中分离ARV强烈表明从育种者向后代的垂直传播.

结论:

在中国的肉养殖场中,低毒性和高毒性ARV菌株的同时流通很普遍.
从繁殖群体的垂直传播在ARV的传播和维持中起着重要的,往往被低估的作用.
研究结果为制定有效的预防和控制策略提供了关键数据,以预防禽类ARV诱导的关节炎.

关键词:

鸟类的奥托雷病毒 (ARV)SNT; 致病性; 致病性隔离隔离隔离隔离隔离多个基因型的多个基因型.血清发生率的普遍性.

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