在COVID-19疫苗接种后的视神经炎:对疫苗不良事件报告系统的分析
Mustafa Jaffry1, Owais M Aftab, Fahad B Mostafa
1Department of Neurology (MJ, OMA, IF, KJ, KM, NS), Rutgers New Jersey Medical School, Newark, New Jersey; Department of Mathematics and Statistics (FBM), Texas Tech University, Lubbock, Texas; Department of Marketing (SR, KJ), Columbia Business School, New York City, New York; and Department of Public Health (HK), Texas Tech University Health Sciences Center, Lubbock, Texas.
概括
视神经炎 (ON) 报告在COVID-19疫苗接种后增加,但仍在正常人口发病率范围内. 男性性别与接种疫苗后的永久性残疾有关.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 视神经炎 (ON) 是一种影响视神经的炎症状况.
- 调查COVID-19疫苗接种和ON之间的潜在关联对于疫苗安全监测至关重要.
- 了解免疫接种后的不良事件 (AEFI) 有助于公共卫生决策.
研究的目的:
- 调查COVID-19疫苗接种与视神经炎 (ON) 之间的关联.
- 将COVID-19疫苗接种后的ON报告率与历史数据和其他疫苗进行比较.
- 为了确定与疫苗接种后出现ON的患者的更糟糕结果相关的因素.
主要方法:
- 向疫苗不良事件报告系统 (VAERS) 报告的ON病例的回顾性分析.
- 在大流行前,COVID-19大流行和COVID-19疫苗期间的ON报告率的比较.
- 采用了统计分析,包括比例测试,奇平方测试,克鲁斯卡尔-瓦利斯和多变量逻辑回归.
主要成果:
- 与流感和其他疫苗相比,在COVID-19疫苗接种后观察到ON报告率的显著增加 (每100万分之一18.6vs0.2vs0.4).
- 然而,观察到的报告率在一般人群中处于ON的确定的发病率范围之内.
- 男性性别是永久残疾,急诊室访问或住院治疗的唯一显著预测因素.
结论:
- 虽然一些ON病例可能暂时与COVID-19疫苗有关,但与人口发病率相比,总体报告率没有显著增加.
- 由于被动监测的局限性,需要进行进一步的受控研究来确定因果关系.
- 持续的监测和研究对于了解疫苗安全概况至关重要.
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