菌酸莫菲蒂尔在儿科免疫性血小板缺血中使用,耐药于一线治疗:单中心体验
Tracie A Goldberg1, Carolyn Fein Levy2,3
1The Rina Zaizov Division of Pediatric Hematology-Oncology, Schneider Children's Medical Center, Petah Tikva, Israel.
Journal of pediatric hematology/oncology
|June 14, 2023
概括
菌酸莫菲蒂尔 (MMF) 为患有慢性免疫性血栓缺血症 (ITP) 的儿童提供了有前途的治疗方法,这些儿童对初始疗法没有反应. 这项研究显示了高响应率与可管理的副作用,建议货币货币基金作为一个可行的选择.
科学领域:
- 儿科血液学 儿科血液学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 免疫性血栓缩 (ITP) 影响了许多儿童,其中很大一部分患有慢性疾病.
- 目前慢性ITP的二线治疗具有风险,例如长期免疫抑制的感染易感性增加.
研究的目的:
- 评估mycophenolate mofetil (MMF) 作为治疗儿科免疫性血小板缺血症 (ITP) 的第二线治疗的疗效和安全性.
主要方法:
- 一组16名患有耐火性ITP的儿科患者接受了MMF,剂量增加至2400mg/m2/d.
- 密切监测治疗结果,反应率和不良事件.
主要成果:
- 在患有慢性ITP的儿科患者中,MMF治疗实现了73%的应答率.
- 与MMF相关的不良事件主要是轻微的,并且耐受良好.
- 获得完全响应的患者成功断了MMF,维持了持续的缓解.
结论:
- 菌酸莫菲蒂尔 (MMF) 显示出显著的疗效和有利的安全性概况,用于管理对第一线治疗无反应的儿科免疫血栓塞缩症 (ITP).
- 货币货币基金对患有慢性ITP的儿童来说是一个有价值的治疗选择,提供持续的反应和可管理的副作用.
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