戒断他类药物的影响感知和客观肌肉功能
Paul Peyrel1,2, Pascale Mauriège1,2, Jérôme Frenette3,4
1Department of Kinesiology, Université Laval, Québec, Québec, Canada.
类他类药物相关的肌肉症状 (SAMS) 通常会导致药物停用. 在SAMS报告者中,在戒断他类药物后,肌肉功能客观上有所改善,同时症状强度降低,这表明有显著的nocebo效应.
科学领域:
- 心血管医学 心血管医学
- 药理学 药理学是指药理学的学科.
- 神经学 神经学
背景情况:
- 类他类药物相关的肌肉症状 (SAMS) 很常见,但对肌肉功能的客观数据很少.
- 在SAMS中潜在的nocebo效应可能会混客观评估.
- 了解SAMS需要评估主观和客观的肌肉功能指标.
研究的目的:
- 在报告SAMS的患者中,评估在戒除他类药物后主观和客观肌肉功能的改善.
- 通过客观地测量肌肉功能来区分真正的SAMS和nocebo效应.
- 评估停止使用他类药物对肌肉力量,耐力和功率的影响.
主要方法:
- 招募了三个队列:SAMS的他类药物使用者 (n=61),没有症状的他类药物使用者 (n=15) 和对照者 (n=16).
- 使用动力计测量腿部伸缩/屈曲力,耐力,动力和手握力.
- 通过10点视觉模拟量表 (VAS) 评估SAMS强度,在戒除他类药物前两个月和两个月后.
主要成果:
- 在所有参与者中,在戒断后的腿部肌肉耐力和力量 (7.2-13.3%) 和 flexor 力量 (13.3%) 显著改善 (p≤0.02).
- SAMS组在腿部肌肉功能 (8.8-16.6%) 和手握强度 (4.0-6.2%) 中显著改善,VAS得分降低 (5.09至1.85).
- 没有SAMS组在戒断后体验到手握强度下降 (-1.7%至-4.2%).
结论:
- 报告SAMS的患者经历了客观的肌肉功能改善和降低症状强度后,他类药物戒断.
- 研究结果表明,SAMS中存在nocebo效应的重要组成部分,以及潜在的真实肌肉毒性.
- 临床医生应监测脆弱的他类药物使用者的肌肉功能,考虑客观措施和主观报告.
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