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相关概念视频

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

837
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
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Immunological Memory01:23

Immunological Memory

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Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Overview
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Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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相关实验视频

Updated: Jul 26, 2025

Single-cell Screening Method for the Selection and Recovery of Antibodies with Desired Specificities from Enriched Human Memory B Cell Populations
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CD62L表达标志着SARS-CoV-2记忆B细胞子集,具有中和表位的偏好.

Taishi Onodera1, Nicolas Sax2, Takashi Sato3

  • 1Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Tokyo, Japan.

Science advances
|June 14, 2023
PubMed
概括

针对SARS-CoV-2的强有力的中和抗体来源于表达较高CD62L的特定记忆B细胞 (Bmem). 这一子集表现出独特的特征,促进了对COVID-19幽默免疫的理解.

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科学领域:

  • 免疫学 免疫学 免疫学
  • 病毒学 病毒学
  • 分子生物学分子生物学

背景情况:

  • 严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 中和抗体主要向尖端受体结合域 (RBD).
  • 结合RBD的记忆B细胞 (Bmem) 表现出异质的中和活动,需要表型表征.

研究的目的:

  • 确定Bmem细胞的表型,这些Bmem细胞含有强大的SARS-CoV-2中和抗体,用于从COVID-19中康复的个体.
  • 了解针对SARS-CoV-2的有效幽默保护的免疫基础.

主要方法:

  • 结合单个Bmem细胞分析与功能抗体评估.
  • 分析了CD62L表达,表位偏好和RBD结合Bmem细胞中的VH基因使用情况.

主要成果:

  • 鉴定出一种中和Bmem细胞的子集,其特征是CD62L表达升高.
  • 这种CD62L+子集显示出明显的表位特异性和融合的VH基因使用,与中和抗体标位相关.
  • 在CD62L+和CD62L-子集之间,RBD结合是相当的,但它们的动力学因COVID-19的严重程度而异.

结论:

  • 已经揭示了与强大的SARS-CoV-2中和相关的Bmem细胞的独特表型.
  • 较高的CD62L表达标志着Bmem细胞产生高度有效的中和抗体.
  • 这一发现增强了对COVID-19感染后B细胞记忆和幽默免疫力的理解.