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吸收后肌肉蛋白质合成在门诊患者中比在住院患者中更高

Paul T Reidy^1,2, Michael S Borack¹, Jared M Dickinson¹

¹Center for Metabolic Health, University of Texas Medical Branch, Galveston, Texas, United States.

American journal of physiology. Endocrinology and metabolism

|June 14, 2023

概括

与门诊患者相比,住院患者在禁食后表现出较低的肌肉蛋白合成 (MPS). 即使是门诊患者的最小早晨步骤也显著提高了MPS,突出了体育活动的影响.

科学领域:

运动生理学运动生理学
营养生物化学营养生物化学
代谢研究研究代谢研究

背景情况:

肌肉蛋白质合成 (MPS) 对肌肉健康至关重要,并受到营养和活动状态的影响.
吸收后状态为评估基底MPS提供了一个独特的窗口,受先前活动水平的影响.
住院治疗,特别是住院治疗,往往涉及到长时间的不活动,可能会影响像MPS这样的代谢过程.

研究的目的:

研究住院患者与门诊患者状态对后吸收性肌肉蛋白合成 (MPS) 的影响.
为了确定早晨体育活动的差异是否有助于在住院患者和门诊患者之间MPS的变化.

主要方法:

追溯分析比较了152名门诊患者和350名接受MPS评估的住院患者.
使用稳定的同位素方法和大量的横向肌肉活检来测量混合MPS在2-3小时间隔.
对参与者的子集进行量化的早晨步骤,以评估身体活动水平.

主要成果:

门诊患者显示,与住院患者相比,MPS后吸收率大约高出12% (P < 0.05).
与住院患者相比,门诊患者在评估过程中采取了显著更多的步骤 (800-900),尽管有限制活动的指示.
身体活动的最小增加 (约. 900个步骤) 足以提高吸收后的MPS.

结论:

一晚住院住院与早上体力活动减少和后吸收MPS显著下降有关.
身体活动,即使在低水平,在调节MPS在后吸收状态中发挥着关键作用.
研究人员在设计研究和解释MPS数据时必须考虑患者活动状态.

关键词:

设计设计设计设计在住院患者.肌肉肌肉肌肉肌肉肌肉门诊患者的治疗方式一个步骤,一个步骤,一个步骤.

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