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相关概念视频

Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

7.3K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
7.3K
Cell Migration01:19

Cell Migration

4.9K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
4.9K
Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

2.7K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
2.7K
Extracellular Matrix01:26

Extracellular Matrix

3.0K
Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
3.0K
Morphogenesis02:19

Morphogenesis

28.5K
Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.
28.5K
The Extracellular Matrix01:29

The Extracellular Matrix

9.1K
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
9.1K

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相关实验视频

Updated: Jul 26, 2025

Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix
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Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix

Published on: July 10, 2016

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组织形态发生通过动态细胞和矩阵相互作用.

Di Wu1, Kenneth M Yamada2, Shaohe Wang1

  • 1Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, USA;

Annual review of cell and developmental biology
|June 14, 2023
PubMed
概括
此摘要是机器生成的。

粘附分子和细胞外矩阵通过调解细胞相互作用来指导组织发育. 物理力和生化信号驱动组织形态发生,塑造各种组织结构.

关键词:
底层膜的底层膜.卡德林是个非常有趣的人.细胞粘附 细胞粘附细胞外矩阵是细胞外矩阵.整体的整体是整体的表面之间的张力.

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Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
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Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration

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Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion

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相关实验视频

Last Updated: Jul 26, 2025

Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix
08:49

Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix

Published on: July 10, 2016

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Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
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Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration

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Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion
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Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion

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科学领域:

  • 细胞生物学 细胞生物学
  • 生物物理学的生物物理.
  • 发展生物学 发展生物学

背景情况:

  • 多细胞生物通过由粘附分子介导的细胞-细胞和细胞-矩阵相互作用形成组织.
  • 这些相互作用对组织完整性至关重要,并调节组织形态发生.
  • 细胞感知并响应环境线索,影响它们的行为和矩阵特性.

研究的目的:

  • 审查矩阵和粘附分子在组织形态发生中的作用.
  • 强调推动组织发育的物理相互作用.

主要方法:

  • 文献综述侧重于细胞矩阵和细胞之间的相互作用.
  • 对参与细胞环境传感的信号通路的分析.
  • 检查组织重塑中的物理力量.

主要成果:

  • 粘附分子是组织形态发生的中央调节者.
  • 关于细胞分裂,分化,迁移和生存的细胞决策受到环境感知的影响.
  • 组织形态是由细胞和矩阵的动态重塑造成的.

结论:

  • 了解粘附分子,细胞外矩阵和物理力之间的相互作用是组织形态发生的关键.
  • 物理相互作用是组织形状和功能发展的关键驱动因素.