从不同的血糖状态到心血管疾病的进展:基于多状态模型的前性研究
Yarong Chen1, Lulu Xu1, Zhiyuan Cheng2
1Institution of Epidemiology and Statistics, School of Public Health, Lanzhou University, 199 Donggang West Road, Lanzhou, Gansu 730000, China.
European journal of preventive cardiology
|June 14, 2023
概括
了解从糖尿病前期到2型糖尿病 (T2DM) 和心血管疾病 (CVD) 的疾病进展至关重要. 在糖尿病前期进行干预为恢复正常血糖和预防严重心血管事件提供了最佳机会.
科学领域:
- 心血管流行病学心血管流行病学
- 代谢性疾病研究研究.
- 公共卫生 公共卫生
背景情况:
- 心血管疾病 (CVD) 和2型糖尿病 (T2DM) 是全球主要的健康问题.
- 了解从正常血糖血症到糖尿病前期,再到T2DM和心血管疾病的进展,对于有效的预防策略至关重要.
研究的目的:
- 量化疾病过渡率从正常血糖到糖尿病前期,T2DM,心血管疾病和心血管死亡.
- 分析各种风险因素对这些过渡率的影响.
主要方法:
- 利用了金队列研究 (42,585名成年人) 的数据.
- 应用多状态模型来分析疾病进展和风险因素关联,平均7年随访时间.
- 追踪过渡包括正常血糖,糖尿病前期,T2DM,心血管疾病和心血管死亡.
主要成果:
- 确定了从并发性冠心病 (CHD) 和中风到心血管死亡的高过渡率,以及从单独的中风到心血管死亡的高过渡率.
- 糖尿病前期的停留时间为6.77年,通过控制体重,脂质,血压和尿酸,有可能恢复正常血糖.
- 与正常血糖症相比,T2DM和糖尿病前期显著增加了过渡率到心脏病和中风.
- 年龄和高血压加速了大多数转变;超重/肥胖,吸烟,脂质不良和高尿血症发挥了重要作用.
结论:
- 糖尿病前期是干预预防T2DM和CVD进展的关键窗口.
- 该研究提供了关于过渡率,停留时间和风险因素的宝贵数据,以告知T2DM和CVD的初级预防工作.
相关概念视频
01:30Coronary Artery Disease I: Introduction
33
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
33
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
204
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
204
01:02Glucose Homeostasis: Regulation of Blood Glucose
1.8K
Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
1.8K
01:25Errors occurring during blood pressure monitoring
787
Blood pressure monitoring is a crucial clinical procedure in diagnosing and managing various cardiovascular conditions. Despite its significance, the accuracy of blood pressure measurements can be compromised by multiple factors, potentially leading to either falsely high or low readings. These inaccuracies are critical as they can significantly impact patient care. So, it is vital to understand these challenges deeply and adopt strategic approaches to minimize errors.
Several factors...
Several factors...
787
01:28Factors affecting Blood pressure
3.4K
Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:
Physiological Factors:
3.4K
01:16Hormones Regulating Blood Glucose
3.6K
Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...
In addition to accelerating glucose uptake and utilization, insulin has...
3.6K