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Updated: Jul 26, 2025

An Ecdysone Receptor-based Singular Gene Switch for Deliberate Expression of Transgene with Robustness, Reversibility, and Negligible Leakiness
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基于工程核激素受体的哺乳动物基因表达的多输入药物控制开关

Simon Kretschmer1,2, Nicholas Perry1,2,3, Yang Zhang1,2

  • 1Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California 94158, United States.

ACS synthetic biology
|June 14, 2023
PubMed
概括

使用核激素受体 (NHRs) 的工程蛋白质开关能够精确控制细胞输出. 这些合成生物学工具允许使用多种药物同时调整基因表达.

关键词:
细胞工程 细胞工程这是模块化的模块化.多输入开关 多输入开关核激素受体 核激素受体蛋白质工程工程 蛋白质工程合成生物学 合成生物学

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