关于中国大湾区精密瘤学的共识声明
Tai-Chung Lam1, William Chi-Shing Cho2, Joseph Siu-Kie Au3
1Department of Clinical Oncology, Queen Mary Hospital/Hong Kong University-Shenzhen Hospital, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
JCO precision oncology
|June 14, 2023
概括
中国大湾区 (GBA) 的精密瘤学 (PO) 正在标准化. 精密瘤工作组 (POWG) 的共识声明将指导下一代测序综合基因组组 (NGS CGPs) 的临床应用,以改善癌症护理.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 精准医学是一门精准的医学.
背景情况:
- 下一代测序综合基因组面板 (NGS CGPs) 能够实现个性化癌症治疗.
- 在中国大湾区 (GBA) 内的临床实践的区域差异需要对精确瘤学 (PO) 采取统一的方法.
- 加强合作对于有效地将PO纳入GBA至关重要.
研究的目的:
- 为分子分析和基因组改变解释的临床应用建立标准化原则.
- 调整可操作的突变与序列导向疗法,以改善癌症患者的治疗结果.
- 为中国GBA的癌症患者提供卓越,基于证据的临床服务.
主要方法:
- 采用了经过修改的Delphi方法,涉及30名专家.
- 支持共识陈述的证据使用GRADE系统进行了分级.
- 报告遵循了质量改善报告卓越 (SQUIRE) 准则的修订标准,版本2.0.0.
主要成果:
- 精密瘤工作组 (POWG) 在六个关键声明上达成共识.
- 关键领域包括NGS报告和质量保证的协调,分子瘤委员会,教育,研究,患者参与,法规,报销和临床实施.
- 这些声明旨在标准化PO交付和实用性.
结论:
- POWG的共识声明标准化了NGS CGP的临床应用,基因组改变的解释和治疗对齐.
- 这些指导方针旨在协调在中国的GBA精密瘤的实用性和交付.
- 该共识通过标准化的精确瘤实践,促进基于证据的高质量癌症护理.
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