多发性硬化和癌症风险之间的关联:一个广泛的审查/元和门德尔随机化分析分析
Qiangzhao Liu1, Jian Kang1, Yongsheng Yin1
1Department of Urology, Gansu Provincial Hospital, Lanzhou, Gansu 730000, PR China.
Multiple sclerosis and related disorders
|June 14, 2023
概括
多发性硬化症 (MS) 患者对某些癌症的风险发生变化. 分析表明胰腺和卵巢癌的风险较高,但孟德尔随机化发现与乳腺癌和肺癌发病率增加的反向关系.
科学领域:
- 神经免疫学 神经免疫学
- 在瘤学瘤学.
背景情况:
- 关于多发性硬化症 (MS) 患者的癌症风险存在矛盾的发现.
- 本研究评估了MS和癌症发病率之间的相关性和因果关系.
研究的目的:
- 进行全面的审查和元分析,以评估多发性硬化和癌症发病率之间的相关性.
- 通过使用孟德尔随机化来研究潜在的因果关系和MS和癌症风险之间的潜在机制.
主要方法:
- 在Cochrane Library,PubMed和Embase数据库中进行系统的文献搜索.
- 对18篇精选文章 (368,952名患者) 的元分析,研究了14种不同的癌症类型.
- 两个样本的孟德尔随机化 (MR) 分析,以探索MS介导的癌症调节.
主要成果:
- 综合分析显示,MS患者的胰腺癌 (ES=0.68) 和卵巢癌 (ES=0.65) 发病率降低.
- 在MS患者中观察到乳腺癌 (ES=1.10) 和脑癌 (ES=1.94) 发病率升高.
- 核磁共振分析表明,多发性硬化和乳腺癌风险 (OR=0.94392) 与肺癌发病率增加 (OR=1.0004) 之间存在反向关系.
结论:
- 分析表明,MS患者胰腺,卵巢,乳腺和脑癌的风险发生变化.
- 门德尔随机化提供了对因果关系的见解,突出了与乳腺癌和肺癌风险增加的反向关联.
相关概念视频
Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
Mismatch Repair
4.9K
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
4.9K
Psychoneuroimmunology: Diabetes and Cancer
50
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
50
Cancer Survival Analysis
402
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
402
Cancers Originate from Somatic Mutations in a Single Cell
12.1K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
12.1K
Genome-wide Association Studies-GWAS
13.6K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.6K


