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规范的BAF复杂活动塑造了授权CD8T细胞效应器和记忆命运的增强器景观

Bryan McDonald1, Brent Y Chick2, Nasiha S Ahmed3

  • 1NOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Biomedical Sciences Graduate Program, University of California at San Diego, La Jolla, CA 92093, USA.

Immunity
|June 14, 2023
PubMed
概括

通过ARID1A,正规的BAF (cBAF) 综合体在CD8+ T细胞中重塑染色质,使得效应细胞和记忆细胞的分化. 它的缺失会损害增强器的可访问性,导致分化失败和减少抗病毒反应.

关键词:
在 ARID1A 中.在BAF复杂的 BAF复杂.CD8 (((+) T细胞是T细胞中的一个.抗病毒免疫力抗病毒免疫力染色体重塑 染色体重塑 的方法效应细胞T细胞的效应细胞.表观遗传学是指表观遗传学.免疫疗法 免疫疗法记忆T细胞是T细胞的一个组成部分.

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