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Updated: Jul 26, 2025

Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation
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Published on: September 20, 2017

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SWI/SNF染色体重塑复合体BAF和PBAF在耗尽的CD8+ T细胞中差异调节表观遗传过渡

Amy E Baxter1, Hua Huang2, Josephine R Giles3

  • 1Institute for Immunology and Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

Immunity
|June 14, 2023
PubMed
概括

两个SWI/SNF复合体,BAF和PBAF,可以控制CD8+T细胞耗尽 (Tex). PBAF保留了Tex原始细胞,而BAF产生了Tex效应细胞,影响了癌症免疫疗法.

关键词:
在BAF中,BAF是BAF.在CRISPR-Cas9屏幕上这就是PBAF的PBAF.在 SWI/SNF 中.T细胞耗尽的情况在T细胞的记忆中.染色质改造复合体的复合物表观遗传学是指表观遗传学.免疫疗法 免疫疗法

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