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Updated: Jul 26, 2025

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
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鉴定导致自身炎症的IL-1受体突变指导IL-1向药物设计

Yusha Wang1, Jun Wang2, Wenjie Zheng3

  • 1Life Sciences Institute, Zhejiang University, Hangzhou 310058, Zhejiang, China; Liangzhu Laboratory, Zhejiang University, Hangzhou 311121, Zhejiang, China.

Immunity
|June 14, 2023
PubMed
概括

一种新的IL-1R1变体通过破坏IL-1Ra结合导致自身炎症性疾病. 这项研究确定了IL-1驱动的炎症状况的新治疗点.

关键词:
这就是CRMO.一个IL-1陷它们的IL-1R1型是IL-1R1.在 IL-1Ra 系统中,IL-1Ra 是在 LIRSASA 里.通过NF-κB路径.自发炎性疾病自发炎性疾病.骨质细胞生成 (osteoclastogenesis) 是一个过程.里拉布纳塞普特 (rilabnacept) 是一个药物.

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