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基于细胞工厂的牛奶蛋白生物制造:进展和前景

Mengting Deng¹, Xueqin Lv¹, Long Liu¹

¹Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China; Science Center for Future Foods, Jiangnan University, Wuxi 214122, China; Engineering Research Center of Ministry of Education on Food Synthetic Biotechnology, Jiangnan University, Wuxi 214122, China; Jiangsu Province Engineering Research Center of Food Synthetic Biotechnology, Jiangnan University, Wuxi 214122, China.

International journal of biological macromolecules

|June 14, 2023

概括

合成生物学使微生物细胞工厂能够生产牛奶蛋白质,提供可扩展的替代蛋白质来源. 虽然在经济上是可行的,但生产效率和安全方面的挑战需要进一步研究细胞农业.

科学领域:

合成生物学合成生物学
生物技术是生物技术.
食品科学食品科学食品科学

背景情况:

全球人口增长和蛋白质需求需要新的食品供应解决方案.
微生物细胞工厂为生产替代蛋白质提供了一种可持续的方法.
牛奶蛋白,包括素,α-乳蛋白和β-乳球蛋白,是生物生产的关键标.

研究的目的:

审查建立基于合成生物学的微生物细胞工厂,用于牛奶蛋白生物生产.
评估基于细胞工厂的牛奶蛋白生产的经济可行性.
识别挑战,并为工业应用提出解决方案.

主要方法:

牛奶蛋白的组成,含量和功能的总结.
基于细胞工厂的牛奶蛋白生产的经济分析.
审查生物制造当前的挑战和潜在的改进.

主要成果:

基于细胞工厂的牛奶蛋白生产在工业规模上是经济可行的.
可以产生关键的牛奶蛋白质,如素,α-乳酸蛋白和β-乳糖球蛋白.
生产效率,功能性质调查和食品安全评估仍然是一个挑战.

结论:

通过微生物细胞工厂生物制造牛奶蛋白是细胞农业的一个有希望的途径.
需要在遗传工具,蛋白质工程和净化方面取得进一步的进步.
应对当前的挑战将促进替代蛋白质的广泛采用.

关键词:

替代蛋白质是一种替代蛋白质.基于细胞工厂的牛奶蛋白质.合成生物学合成生物学

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