与衰老过程中男性生殖功能变化相关的机制
Ayodeji Folorunsho Ajayi1, Moyinoluwa Comfort Onaolapo2, Ayomide Isaac Omole2
1Department of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria; Anchor Biomed Research Institute, Ogbomoso, Oyo State, Nigeria.
Experimental gerontology
|June 14, 2023
概括
随着年龄的增长,男性的生殖健康因氧化压力和荷尔蒙变化等因素而下降. 抗氧化剂和适当的营养可以支持精液质量和男性生育能力.
科学领域:
- 生殖生物学 生殖生物学
- 老年学是一门学科.
- 安德罗学与人类学
背景情况:
- 衰老与影响男性生殖能力的生理变化有关.
- 有几个因素导致与年龄相关的男性生殖功能障碍,包括氧化应激,慢性疾病,感染,肥胖和毒素积累.
- 晚年和精液的关键参数之间存在负相关性,如体积,数量,运动性,活力和形态,导致不孕.
研究的目的:
- 探索衰老对男性生殖功能的多方面的影响.
- 阐明氧化压力,荷尔蒙失衡和生活方式因素在与年龄相关的男性不孕症中的作用.
- 突出抗氧化剂和微量营养素在老化期间维持男性生殖健康的潜在益处.
主要方法:
- 文献综述和现有关于衰老和男性生殖健康的研究综合.
- 分析与男性衰老相关的生理和生化变化.
- 检查反应性氧物种 (ROS) 和抗氧化剂系统对精子质量的影响.
主要成果:
- 衰老与精液量,精子数量,渐进性运动性,活力和正常形态相成比例.
- 生殖组织中高水平的活性氧物种 (ROS) 会导致精子细胞的破坏和不孕.
- 抗氧化剂 (维生素C,E,β-胡卜素) 和微量营养素 (,叶酸) 支持正常的精液质量和生殖功能.
- 荷尔蒙失衡,下丘脑-垂体-阴茎轴功能障碍,塞尔托利/莱迪格细胞障碍和氧化介导的勃起功能障碍在老年男性中具有重要意义.
结论:
- 衰老通过各种生理和生化途径显著损害男性的生殖能力.
- 氧化应激和荷尔蒙失调是与年龄相关的男性不孕症的关键因素.
- 保持足够的抗氧化剂状态和解决潜在的健康状况对于在衰老期间保持男性生殖健康至关重要.
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