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Updated: Jul 26, 2025

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale
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Published on: May 28, 2021

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另一种皮肤屏障模型和切割的人体皮肤的并行评估,用于皮肤吸收的研究 in vitro

Alec T Salminen1, Kelly J Davis2, Robert P Felton3

  • 1Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA.

Toxicology in vitro : an international journal published in association with BIBRA
|June 14, 2023
PubMed
概括

这项研究评估了用于预测人类皮肤吸收的替代皮肤屏障模型. 重建的人类表皮 (RhE) 模型显示出希望,为安全性评估提供了切除的人类皮肤 (EHS) 的可行替代方案.

关键词:
皮肤吸收 皮肤吸收弗朗茨的细胞是弗朗茨的细胞.人的皮肤 人的皮肤在体外透测试中进行透测试.重建的人类表皮.这就是Strat-M.

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Methods for Studying Drug Absorption: In vitro01:16

Methods for Studying Drug Absorption: In vitro

In vitro experiments are crucial for understanding the transport and absorption of drugs through biological materials. These studies employ varied methods such as the diffusion cell method, the everted sac technique, and the everted ring technique.
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
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