Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

16
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
16

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Quantum Teleportation over Thermal Microwave Network.

Physical review letters·2026
Same author

The calcimimetic etelcalcetide restores cardiac function in chronic hyperphosphatemia via calcium sensing receptor-cAMP activation.

Kidney international·2026
Same author

Evaluating the impact of polypropylene-based cat litter on urinalysis reliability in feline patients.

Polish journal of veterinary sciences·2025
Same author

Bunch length measurement setup for femtocoulomb bunch charges at the superconducting Darmstadt electron linear accelerator S-DALINAC.

The Review of scientific instruments·2025
Same author

[Guide to the application of the 9th TNM classification for lung cancer : Statement/position paper of the Thoracic Pathology Working Group].

Pathologie (Heidelberg, Germany)·2025
Same author

'Learning from post COVID-19 condition for epidemic preparedness'-author's response.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2025

相关实验视频

Updated: Jul 26, 2025

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
09:16

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Published on: June 3, 2018

7.3K

Ythdf2通过其mRNA标转录来调节心脏重塑.

V Kmietczyk1, J Oelschläger1, P Gupta1

  • 1Department of Internal Medicine III (Cardiology, Angiology, and Pneumology), Heidelberg University Hospital, 69120 Heidelberg, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120 Heidelberg, Germany.

Journal of molecular and cellular cardiology
|June 14, 2023
PubMed
概括

m6A读者蛋白Ythdf2调节心肌细胞的功能. 它的删除会损害心脏功能并增加纤维化,揭示了心脏衰竭中基因表达控制的新机制.

关键词:
在Eef2Eef2Eef2心脏衰竭是因为心脏衰竭.翻译 翻译 翻译 翻译这就是 Ythdf22.m(6) A6) 一个

更多相关视频

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy
11:51

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

Published on: March 1, 2016

10.4K
Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents
07:26

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Published on: July 14, 2021

5.1K

相关实验视频

Last Updated: Jul 26, 2025

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
09:16

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Published on: June 3, 2018

7.3K
Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy
11:51

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

Published on: March 1, 2016

10.4K
Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents
07:26

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Published on: July 14, 2021

5.1K

科学领域:

  • 心血管生物学 心血管生物学
  • 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
  • 分子心脏病学分子心脏病学

背景情况:

  • N6-甲基氨酸 (m6A) mRNA甲基化对心肌细胞功能至关重要.
  • 在心力衰竭中观察到升高的m6A水平,但m6A读取蛋白的作用仍然不清楚.

研究的目的:

  • 研究m6A读者蛋白Ythdf2在心肌细胞功能和心力衰竭中的作用.
  • 确定m6A读者蛋白调节基因表达和心脏功能的新机制.

主要方法:

  • 在体内研究涉及心肌细胞特异性Ythdf2删除在小鼠.
  • 在体外对心肌细胞中Ythdf2的抑制.
  • 特定于细胞类型的Ribo-seq分析以确定Ythdf2目标.

主要成果:

  • 心肌细胞中Ythdf2的缺失导致心脏缩,心脏功能减弱,在压力过重和衰老下纤维化增加.
  • 在实验室中,Ythdf2的淘汰导致心肌细胞的生长和重塑.
  • 核细胞延长因子2被确定为Ythdf2介导的转录后调节的直接目标.

结论:

  • m6A读者蛋白Ythdf2在维持心肌细胞功能和预防心脏功能障碍方面发挥着至关重要的作用.
  • Ythdf2调节基因表达,包括真核延长因子2,影响心脏重塑和功能.
  • 这项研究增强了对m6A甲基化对心肌细胞的调节作用和Ythdf2对心脏功能的控制的理解.