相关实验视频

Updated: Jul 26, 2025

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Published on: June 3, 2018

Ythdf2通过其mRNA标转录来调节心脏重塑

V Kmietczyk¹, J Oelschläger¹, P Gupta¹

¹Department of Internal Medicine III (Cardiology, Angiology, and Pneumology), Heidelberg University Hospital, 69120 Heidelberg, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120 Heidelberg, Germany.

Journal of molecular and cellular cardiology

|June 14, 2023

概括

m6A读者蛋白Ythdf2调节心肌细胞的功能. 它的删除会损害心脏功能并增加纤维化,揭示了心脏衰竭中基因表达控制的新机制.

科学领域:

心血管生物学心血管生物学
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
分子心脏病学分子心脏病学

背景情况:

N6-甲基氨酸 (m6A) mRNA甲基化对心肌细胞功能至关重要.
在心力衰竭中观察到升高的m6A水平,但m6A读取蛋白的作用仍然不清楚.

研究的目的:

研究m6A读者蛋白Ythdf2在心肌细胞功能和心力衰竭中的作用.
确定m6A读者蛋白调节基因表达和心脏功能的新机制.

主要方法:

在体内研究涉及心肌细胞特异性Ythdf2删除在小鼠.
在体外对心肌细胞中Ythdf2的抑制.
特定于细胞类型的Ribo-seq分析以确定Ythdf2目标.

主要成果:

心肌细胞中Ythdf2的缺失导致心脏缩,心脏功能减弱,在压力过重和衰老下纤维化增加.
在实验室中,Ythdf2的淘汰导致心肌细胞的生长和重塑.
核细胞延长因子2被确定为Ythdf2介导的转录后调节的直接目标.

结论:

m6A读者蛋白Ythdf2在维持心肌细胞功能和预防心脏功能障碍方面发挥着至关重要的作用.
Ythdf2调节基因表达,包括真核延长因子2,影响心脏重塑和功能.
这项研究增强了对m6A甲基化对心肌细胞的调节作用和Ythdf2对心脏功能的控制的理解.

关键词:

在Eef2Eef2Eef2 心脏衰竭是因为心脏衰竭.翻译翻译翻译翻译这就是 Ythdf22.m(6) A6) 一个

更多相关视频

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

Published on: March 1, 2016

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Published on: July 14, 2021

相关概念视频

Heart Failure II: Pathophysiology

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...