开发和分析用于胃肠道研究的多模块围模拟器
Clay Swackhamer1, Tesfaye Bedane2, Silvia Keppler1
1Department of Biological and Agricultural Engineering, University of California, Davis, USA.
Food research international (Ottawa, Ont.)
|June 14, 2023
概括
一种新的体外消化装置模拟了多达12个样本的胃肠周立体,为食品特性提供了高通量分析. 这个系统准确地模仿了人类的消化机动性,用于高级研究.
科学领域:
- 生物医学工程 生物医学工程
- 胃肠病学 胃肠病学
- 食品科学 食品科学 食品科学
背景情况:
- 现有的体外消化系统缺乏准确的对胃肠周围的模拟.
- 目前生理上相关的系统的吞吐量很低,只能一次检测一个样本.
研究的目的:
- 开发一种能够模拟周周收缩的新型体外消化装置.
- 为了在生理上相关的条件下使食品材料的高通量选成为可能.
主要方法:
- 一个装有12个消化模块的装置,使用可变宽度的滚筒模拟周围静止.
- 调节和测量了力,阻塞和流体动力学.
- 运用了计算流体动力学建模和视频分析的痕迹粒子.
主要成果:
- 模拟的围静收缩产生了从2.61 ± 0.03 N到4.51 ± 0.16 N之间的力.
- 封闭度从72.1 ± 0.4%到84.6 ± 1.2%不等,流体速度与生理范围相匹配.
- 模型预测的和实验测量的流体速度分别为0.016 m/s和0.015 m/s.
结论:
- 这种新型设备准确地模拟了胃肠道的运动,包括阻塞,压力和流体速度.
- 这种灵活的平台支持对食品材料进行高通量选,以寻找健康益处.
- 它代表了体外胃肠道研究的重大进步.
相关概念视频
01:26Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy
114
This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
114
01:20Gastrointestinal Motility Disorders
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Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
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01:22Physiology of the Gastrointestinal System I: Ingestion and Propulsion
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The physiology of the gastrointestinal system begins with ingestion as food enters the mouth.
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